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2008-09
Departmental Performance Report



National Research Council Canada






Supplementary Information (Tables)






Table of Contents




Table 1: Sources of Respendable and Non-Respendable Revenue


Respendable Revenue
($ millions)
Program
Activity
Actual
2006-07
Actual
2007-08
2008-09
Main
Estimates
Planned
Revenue
Total
Authorities
Actual
Research and Development
Fee for Service 54.0 49.5 43.7 43.7 46.3 46.3
Rentals 3.0 3.8 3.3 3.3 3.8 3.8
Royalties 5.5 8.6 3.8 3.8 8.8 8.8
Publications 4.6 3.1     3.7 3.7
Other   0.0 0.8 0.8 5.2 5.2
Revenues Available for Use from Prior Years         57.7  
 
Technology and Industry Support
Fee for Service 7.8 12.6 26.5 26.5 10.4 10.4
Rentals     0.1 0.1    
Royalties            
Publications 15.5 2.2     2.8 2.8
Other 2.7 4.9        
Revenues Available for Use from Prior Years         5.9  
 
Internal Services
Fee for Service     2.2 2.2 5.7 5.7
Rentals     0.4 0.4 0.4 0.4
Royalties            
Publications            
Other     2.7 2.7    
Revenues Available for Use from Prior Years         2.4  
Total Respendable Revenue 83.3 84.6 83.5 83.5 156.6 87.2
Notes:
  1. In accordance with section 5.1 (e) of the National Research Council Act, NRC is authorized to spend its operating revenues and therefore does not net-vote.
  2. Due to rounding, figures may not add to total shown.
  3. Except where noted otherwise, tables are presented on a cash accounting basis for historical comparability.



Table 2: User Fees


Table 2-A: User Fees
($ thousands)
User Fee Fee Type Fee-setting Authority Date Last Modified 2008-09 Planning Years
Forecast
Revenue
Actual
Revenue
Full
Cost
Performance
Standard 1
Performance
Result
Fiscal
Year
Forecast
Revenue
Estimated
Full Cost
Fees charged for the processing of access requests filed under the Access to Information Act (ATIA) Other products and services Access to Information Act 1992 $500 $410 $203,100

This cost includes the salary of the ATIP Coordinator, ATIP Officer and a small percentage of other salaries related to legal services and administration. It includes the costs of a service contract.
Response provided within 30 days following receipt of request; the response time may be extended pursuant to Section 9 of the ATIA. Notice of extension to be sent within 30 days after receipt of request.

The Access to Information Act provides fuller details.
NRC received 23 access to information requests; 35 consultations from other government departments.

NRC routinely waives fees in accordance with TBS guidelines.
2009-10 $500 $250,000
2010-11 $500 $250,000
2011-12 $500 $250,000
Sub-Total (O) $500 $410 $203,100   2009-10 $500 $250,000
2010-11 $500 $250,000
2011-12 $500 $250,000
Total $500 $410 $203,100   2009-10 $500 $250,000
2010-11 $500 $250,000
2011-12 $500 $250,000

Date Last Modified: N/A

Other Information:

National Research Council collects user fees for information requests in accordance to the Access to Information Act. The total user fees collected in 2008-09 included application fees only.

1 According to prevailing legal opinion, where the corresponding fee introduction or most recent modification occurred prior to March 31, 2004:

  • the performance standard, if provided, may not have received parliamentary review; and
  • the performance standards, if provided, may not respect all establishment requirements under the UFA (e.g., international comparison; independent complaint address).
  • the performance result, if provided, is not legally bound to section 5.1 of the UFA regarding fee reductions for unachieved performance.

Table 2-B: External Fees


External Fee Service Standard 1 Performance Results 2 Stakeholder Consultation
Certified Reference Materials Three (3) business days between reception of order and shipping of order Of the 708 orders received this fiscal year, 99.6% met the 3-day standard. 12 of 708 customers responded (1.7% of total)
11 were very satisfied (92% of respondents)
1 was satisfied (8% of respondents)
none were somewhat satisfied (0% of respondents)
none were very dissatisfied (0% of respondents)

Any comments and complaints were investigated and resolved.
Sale of National Code Documents and other documents Orders processed (shipped) 1-14 days after receipt of all required information 94.8% of orders processed within 1-14 days 99.8% satisfaction; in 4783 orders, 9 orders required further follow-up in response to a concern or complaint, all resolved to clients' satisfaction.
1 As established pursuant to the Policy on Service Standards for External Fees:
  • service standards may not have received parliamentary review; and
  • service standards may not respect all performance standard establishment requirements under the UFA (e.g. international comparison; independent complaint address).
2 Performance results are not legally subject to section 5.1 of the UFA regarding fee reductions for unachieved performance.



Table 5: Details of Transfer Payment Programs (TPPs)


  • Industrial Research Assistance Program (NRC-IRAP)
  • Tri-University Meson Facility (TRIUMF)
  • Contributions to International Telescope Programs - Canada-France-Hawaii Telescope (CFHT), James Clerk Maxwell Telescope (JCMT), Gemini Telescopes, Atacama Large Millimeter Array (ALMA)

Name of Transfer Payment Program: Industrial Research Assistance Program (NRC-IRAP)

Start date: 1962-1963

End date: Ongoing

Description: NRC-IRAP provides customized value-added advice, information, referrals and financial assistance to Canadian SMEs and builds effective regional innovation system relationships for the benefit of SMEs. NRC-IRAP works with clients at all stages of the innovation-commercialization continuum, including: project development; access to technical assistance, financial, business, marketing or management advice; access to competitive technical information; patent searches; and access to local, regional, national or international linkages. NRC-IRAP works with organizations that receive NRC-IRAP contributions and others to facilitate the implementation of multi-sector, multi-partner initiatives that are relevant to SMEs regionally and nationally.

Strategic Outcome: An innovative, knowledge-based economy for Canada through research and development, technology commercialization and industry support.

Results Achieved:

Increased SME technical R&D capability and capacityNRC-IRAP continued to support firms in hiring technical expertise such as engineers and scientists, as well as university and college graduates. In 2008-09, NRC-IRAP helped support 5,733 jobs within its SME clients and funded the employment of 540 youth graduates under the Federal Youth Employment Program.

NRC-IRAP co-located almost 75% of its Industry Technology Advisors (ITAs) in research centres, universities, and other industry association offices to help to facilitate SME access to technical assistance on a timely basis. NRC-IRAP contributed to firms technical capability by providing technical, research, and business assistance to Canadian SMEs (8,811 funded and non-funded firms). Field staff assisted SMEs to connect to a large network of diverse industry specific associations such as the Canadian Environmental Technology Advancement Corporation-West and the Board of Governors of Red River College's Advanced Transportation and Energy Centre (ATEC).

NRC-IRAP provided over $9 million in assistance to 142 non-commercial organizations to help them build their capacity to support SMEs. They in turn reached out to over 5,000 SMEs, providing them with, for example, access to research expertise, or equipment and facilities for testing their technology.

Increased SME management, marketing and finance capability and capacityNRC-IRAP has a financial agreement with NRC-CISTI to ensure Program clients benefit from NRC-CISTI's Competitive Technical Information (CTI) services. In 2008-09, NRC-CISTI responded to 1,297 requests for user assistance, technical references, information reports, CTI briefs, CTI assessments, searches, training sessions and presentations.

Under a contribution agreement from NRC-IRAP, the Canadian Manufacturers and Exporters (CME) provided 98 custom management consulting services to SMEs across Canada. Client surveys indicate a high level of satisfaction, with 100% saying they would recommend the Canadian Association of Management Consultants (CMC-Canada)/NRC-IRAP Management Advisory Service to other small businesses.

Growth of firms as a result of technology development project support – A recent Evaluation of NRC-IRAP reported that its client firms experienced growth, both in real and comparative terms. Over the five year evaluation period (2002-2007), client firm sales grew on average by over 28%, overall firm employment grew by 30%, and company assets grew on average by 15%. NRC-IRAP clients on average have greater capabilities and capacity than non-client SMEs, and that the infusion of NRC-IRAP funds had the complimentary effect of inducing firms to increase their spending on R&D. (Source: 2007 Impact Evaluation report)

Enhanced SME connections to technology and business networks to source supportNRC-IRAP maintained local, regional, national and international networks of industry sector, government and community economic development groups, bringing the most appropriate expertise to its clients. NRC-IRAP also continued to support firms and organizations related to NRC technology clusters; and addressed SME needs in the bioproducts industry through techno-business meetings with over 72 participants that resulted in increased awareness of technology opportunities. Furthermore, NRC-IRAP worked with specific industry sectors and communities to join together by hosting events, technology workshops or training sessions that resulted in building strong technology clusters, and enhancing Canadian R&D and commerce presence.

NRC-IRAP has formal agreements with various Canadian institutions. For example, the NRC/NSERC/BDC Joint Strategy to accelerate the commercialization of publicly-funded research; and with NRC-CISTI to provide competitive technical information. An agreement with the Consortium for Research and Innovation in Aerospace (CRIAQ) increased the competitive capacity of Quebec SMEs in aerospace by offering their support in the development and adaptation of new technologies. An agreement with the Atlantic Canada Opportunities Agency (ACOA) fostered the cooperation of Innovation-related activities in the Atlantic region.

The creation of Community of Interest groups, with membership from NRC-IRAP, other parts of NRC and external organizations has increased the sharing of information and creation of knowledge on industry and technology issues which ultimately has contributed to better client service.

Increased adoption/commercialization/collaboration with respect to international endeavours – Two new International Agreements were signed by NRC-IRAP in 2008-09. An agreement with OSEO, the French Agency for Innovation, was established to foster and facilitate close and frequent contact between NRC-IRAP and OSEO to promote the creation of technological partnerships between Canadian and French SMEs; and a collaborative R&D and Technology Partnership with CDTI of Spain. NRC-IRAP has formal and active arrangements with Spain, Ireland, India, China, France, as well as many established relationships with several other countries such as the US, the Scandinavian countries, the Netherlands and the European Union. NRC-IRAP collaborates with these countries on a reciprocal basis to support of SME growth, technology transfer and technology development for the purpose of generating economic benefits. These agreements are an opportunity to build greater partnerships among Canadian, international firms and research institutions.

($ millions)
Program Activity: Technology and Industry Support Actual
Spending
2006-07
Actual
Spending
2007-08
Planned
Spending
2008-09
Total
Authorities
2008-09
Actual
Spending
2008-09
Variance(s)
Total Contributions $76.6 $86.1 $93.0 $87.9 $86.5 $6.5
Total Program Activity(ies) $76.6 $86.1 $93.0 $87.9 $86.6 $6.4

Comment(s) on Variance(s): The variance of $6.4 M includes $5.5 M transfer from NRC-IRAP to NRC-HIA in support of the Telescope Initiative, the remaining $0.9 K is the year-end surplus returned to the NRC Finance Branch.

Audit completed or planned: NRC-IRAP Audits of Recipients have started for 2009/10.



Name of Transfer Payment Program: Tri-University Meson Facility (TRIUMF)

Start date: 1976

End date: Ongoing

Description: TRIUMF, Canada's national facility for research in subatomic physics, is located on the campus of the University of British Columbia in Vancouver. It has been operated since 1968 by a consortium of four Western universities - the University of Alberta, Simon Fraser University, the University of Victoria and the University of British Columbia - under a joint venture agreement. A fifth university, Carleton, joined the consortium on April 1, 2000 and the University of Toronto became the sixth member in April 2005. Seven additional universities (Regina, Manitoba, Guelph, McMaster, Queen's, St. Mary's and Montreal) are associate members.

TRIUMF functions as a national laboratory and as Canada's gateway to international subatomic physics. It houses a particle accelerator that produces energetic beams of mesons and other subatomic particles required for fundamental research in nuclear and particle physics by Canadian and foreign researchers. This research lays the foundation for new technologies in the physical and life sciences and the facility is a major contributor to advanced materials research in Canada and abroad.

Strategic Outcome: An innovative, knowledge-based economy for Canada through research and development, technology commercialization and industry support.

Results Achieved:

General

  • 2,102 visitors including 622 scientists visiting TRIUMF one or more times
  • 157 publications in scientific journals
  • Provided training and employment opportunities for 105 graduate and undergraduate students
  • TRIUMF Accelerator Scientists began teaching a graduate accelerator science course at UBC. Plans are underway to extend the opportunity to other Canadian universities
  • The TRIUMF Five-Year Plan report won the Tom Fairley award for book editing from the Editors' Association of Canada.
  • TRIUMF's main cyclotron was maintained as one of the most reliable in the world at 90% availability
  • TRIUMF received significant publicity during the year, including articles in the Globe and Mail, CBC interviews, a Nature Essay and numerous articles in the CanWest newspaper groups. TRIUMF outreached by delivering community lectures, hosting 8 conferences for 1,159 delegates, producing 5 educational videos, and by hosting a Parliamentary Standing Committee on Industry, Science and Technology to advance Canadian competitiveness in particle and nuclear physics and nuclear medicine.

Nuclear Science
Conducted experiments that were possible nowhere else in the world; setting new world records for accuracy and precision. For example:

  • The DRAGON facility undertook the world's first precision measurement of a nuclear reaction rate that is critical for understanding how stars produce chemical elements. This is important for producing long-lived radioisotopes
  • TRIUMF's Isotope Separator and Accelerator (ISAC) facility developed the world's most intense accelerated isotope beam. The TUDA experiment used this beam to investigate nuclear reactions occurring in novae. The results aided in understanding satellite gamma-ray observatories such as the Gamma-ray Large Area Space Telescope (GLAST)
  • TRIUMF's TITAN facility set world records by performing precision mass measurements of atoms of isotopes shorter-lived and lighter-weight than ever before including the most exotic isotope on earth: Helium-8
  • The ISAC facility accelerated a beam of Rhubidium-80 ions – a world first. ISAC is one of only three facilities in the world with this capability
  • Canadian scientists studied heavy hydrogen and made the first measurement of its chemical reaction rate

Nuclear Medicine

  • A lung cancer hypoxia study patient was scanned for the first time ever in Canada in 2008 at the BC Cancer Agency (BCCA) using an innovative radiotracer developed at TRIUMF. This clinical trial has potential to dictate cancer treatment methods with much improved accuracy.
  • TRIUMF supplied medical isotopes to the BCCA and the Pacific Parkinson's Research Centre.
($ millions)
Program Activity: Research and Development Actual
Spending
2006-07
Actual
Spending
2007-08
Planned
Spending
2008-09
Total
Authorities
2008-09
Actual
Spending
2008-09
Variance(s)
Total Contributions $45.5 $51.5 $43.6 $43.6 $43.5 $0.1
Total Program Activity(ies) $45.5 $51.5 $43.6 $43.6 $43.5 $0.1

Comment(s) on Variance(s):

Audit completed or planned:



Name of Transfer Payment Program: Contributions to International Telescope Programs - Canada-France-Hawaii Telescope (CFHT), James Clerk Maxwell Telescope (JCMT), Gemini Telescopes, Atacama Large Millimeter Array (ALMA)

Start date: 1978

End date: Ongoing

Description: NRC, in partnership with other international bodies, provides financial contributions that support the management and operations of these telescopes and their related facilities and participates in the oversight and direction of the facilities and research. Astrophysics research and development requires large, costly and very precise telescopes and related instruments situated in areas that will provide ideal viewing conditions. It is beyond the capacity of individual firms or even countries to support the costs of developing and maintaining the facilities required for astrophysics research, thus it is necessary for public sector organizations, through international partnerships, to support this R&D.

Strategic Outcome: An innovative, knowledge-based economy for Canada through research and development, technology commercialization and industry support.

Results Achieved:

NRC maintained critical astronomical infrastructure within Canada and contributed to three major international facilities providing Canadian researchers access to forefront research opportunities in the optical and sub-mm spectral windows. In 2008, NRC underwent an international Peer Review in astronomy that concluded that NRC's role is world-class, and establishes Canada as a leading force in both science and technology related to astronomy and astrophysics.

Canadian Astronomy Data Centre – The CADC was integrated into the operations of all the offshore telescopes that NRC operates. During 2008 CADC delivered 1.62 M files comprised of 117 TB of data to 2,772 users.

Canada France Hawaii Telescope – 2008 was the second consecutive year that more than 100 scientific papers were published as a result of research done at this facility. Canadians led three of four new "Large Programmes" approved by the CFHT.

Gemini – Led by NRC's Dr. Christian Marois, a team including several Canadian astronomers used the Gemini Observatory and Marois's novel technique to discover and photograph three planets around HR8799, a nearby star. Dr. Marois was named Scientist of the Year by Radio-Canada and received an NRC Outstanding Achievement Award for his work. Canada enjoyed the highest fraction (>70%) of proposals shared with astronomers from another Gemini partner country. A user survey revealed high satisfaction with support provided to Canadian astronomers by NRC, as well as insight into how both NRC and the Gemini Observatory could improve.

Composite Applications for Radio Telescopes Project (CART) – In three years, NRC developed a leading candidate technology for the future Square Kilometre Array (SKA) world observatory: low-cost, high-performance parabolic reflectors made using composite materials. By September 2008 a production-friendly reflector with improved surface accuracy was ready. It was used to test another novel SKA technology: a custom digital camera for radio imaging. These contributions position Canada among the top technology providers for the SKA.

($ millions)
Program Activity: Research and Development Actual
Spending
2006-07
Actual
Spending
2007-08
Planned
Spending
2008-09
Total
Authorities
2008-09
Actual
Spending
2008-09
Variance(s)
Total Contributions $12.6 $9.2 $5.5 $11.0 $10.5 $(5.0)
Total Program Activity(ies) $12.6 $9.2 $5.5 $11.0 $10.5 $(5.0)

Comment(s) on Variance(s):

Audit completed or planned:




Table 7: Horizontal Initiatives


  • Genomics R&D Initiative (GRDI)

Name of Horizontal Initiative: Genomics R&D Initiative (GRDI)

Name of Lead Department(s): National Research Council Canada

Lead Department Program Activity: Research and Development

Start Date of the Horizontal Initiative: April 1999

End Date of the Horizontal Initiative: March 2011

Total Federal Funding Allocation (start to end date): $234.1 M

Description of the Horizontal Initiative (including funding agreement): The Genomics R&D Initiative was established to build and maintain genomics research capacity in government departments. As an enabling technology, genomics provides powerful tools and precise information to support operational mandates and upon which policy and regulatory decisions can be based. Federal science-based departments and agencies (see part 10 below for listing) interact with partners, stakeholders and clients and link these enabling tools and technologies to value-added applications that enable Canada to respond to national priorities, deliver on government mandates and support the development of wealth for Canadians.

These applications range from international requirements for genomics enabled testing required for exports; the ability to interpret and assess genomics information submitted with product information for regulatory oversight; the development of assays and products using genomics approaches for enhancing Canadian's lives, the environment and sustainability of human activities; socio-economic and ethical considerations related to the use and integration of genomics in health care, environmental sustainability activities, and consumer and industrial products and applications; as well as facilitating Canadians' access to accurate and understandable information concerning genome sciences.

Shared Outcome(s): Enhanced quality of life for Canadians in terms of health, safety, environment, and social and economic development by building and maintaining genomics research capacity in support of key federal public policy objectives; in particular: a) to strengthen innovation and ensure sustainability for the benefit of all Canadians by focusing research in strategic areas of national interest from an economic and social perspective (i.e. health, environment, natural resources and energy, safety and security); b) to promote global competitiveness and expand Canada's international influence by increasing commercialization outcomes of research activities and by improving regulatory efficiency and effectiveness; c) to grow economic opportunities through R&D by building collaborations that involve business, academia and public sectors, in Canada and internationally.

Governance Structure(s): To ensure value for money, the Genomics R&D Initiative established a governance framework to strengthen accountability and to ensure that investments deliver on the promise of making a difference in the lives of Canadians. An interdepartmental Genomics R&D ADM Coordinating Committee was established to oversee the collective management and coordination of the Initiative. The Committee ensures that effective priority setting mechanisms are established within departments and that investments are focused and strategic.

The Committee also ensures that common management principle are implemented and horizontal collaborations between organizations are pursued wherever relevant and possible. The Committee includes members from each of the organizations receiving funding, as well as a representative from Industry Canada.

An Interdepartmental Working Group (WG) supports the work of the Committee. The mandate of the WG is to provide recommendations and advice to the ADM Coordinating Committee regarding strategic priority setting and overall management of the Genomics R&D Initiative. The WG also supports evaluation and reporting requirements related to the Initiative. The NRC, as the lead agency for the Initiative, chairs the ADM Coordinating Committee and the Working Group.

($ millions)
Federal Partners Federal Partner Program Activity (PA) Names of Programs for Federal Partners Total Allocation (from Start to End Date) Planned Spending for
2008-09
Actual Spending for
2008-09
Expected Results for
2008-09
Results Achieved in
2008-09
National Research Council (NRC) Research and Development Genomics and Health Initiative 71 6 6 See Note 1 See Notes 1.1 and 1.2
Agriculture and Agri-Food Canada (AAFC) Innovation and Renewal Canadian Crop Genomics Initiative 71 6 6 See Note 2 See Notes 2.1, 2.2, 2.3, 2.4, 2.5 2.6 and 2.7
Fisheries and Oceans Canada (DFO) Aquaculture Aquatic Biotechnology and Genomics R&D 10 0.9 0.9 See Note 3 See Notes 3.1, 3.2, 3.3, 3.4 and 3.5
Health Canada (HC) Health Products HC/PHAC Genomics Initiative 46 4 3.5 See Note 4 See Notes 4.1, 4.2, 4.3, 4.4, 4.5, 4.6 and 4.7
Natural Resources Canada (NRCan) Natural Resource and Landmass Knowledge for Canadians NRCan-CFS Genomics R&D Initiative 23 2 2 See Note 5 See Notes 5.1, 5.2, 5.3, 5.4 and 5.5
Environment Canada (EC) Canadians Adopt Sustainable Consumption and Production Approaches Strategic Applications of Genomics in the Environment 12 1 1 See Note 6 See Notes 6.1 and 6.2
Canadian Institutes for Health Research (CIHR) N/A - one time allocation in 1999-00 to assist in creation of Genome Canada Secretariat N/A 0.5 N/A N/A N/A N/A
Total 234.1 19.9 19.4    

Notes:

1. Commercially relevant advances in areas of genomics R&D related to human health (e.g. genetic testing, diagnostics, microbial genomic applications, treating and preventing human diseases such as cancer and cardiovascular disease, and pathogen detection).

1.1 Integrated devices that provide rapid, point of care diagnosis of pathogens based on their genomic signature. Central to the success of these devices are on-chip assays that can achieve detection with the sensitivity and specificity necessary to inform sound clinical decisions. In 2008-2009, the Biochips team developed conditions for simultaneous PCR amplification and hybridization of target molecules on the chips, allowing detection of less than 5 molecules of pathogen DNA sequence with a specificity distinguishing a single nucleotide mismatch. This advance brings the detection sensitivity of the assay within the useful clinical range of less than 10 molecules of pathogen per assay, and represents a breakthrough in actualizing on-chip real-time PCR, hybridization and detection of biological samples.

1.2 Building a sustainable pipeline of protein-based tumour-targeting agents that will act as prospective therapeutics is the goal of the GHI Cancer project. On July 7, 2008 Alethia Biotherapeutics, a Canadian biotechnology company engaged in the discovery and development of therapeutics in areas of unmet medical needs, signed an option to license anti-Clusterin monoclonal antibodies (mAbs) developed by the project team. In 2008-2009, in vivo animal studies showed that three of the anti-Clusterin mAbs caused a significant reduction in metastatic nodule production. In addition, an isolated clusterin-binding peptide has been shown effective as an optical imaging agent for tumor cells in animal models and a provisional patent has been filed.

2. Improvements in crop value in cereals, soybean and canola through quality improvements in areas related to plant adaptation to biotic and abiotic stresses (e.g. resistance to disease, tolerance to drought and cold), as well as seed development and metabolism (e.g. related to oil content for biofuels and nutraceutical applications).

2.1 AAFC genomics scientists leveraged GRDI funds to participate in an international collaboration between Canada and Germany. An AAFC scientist and a German colleague co-lead a dedicated group of Canadian and German scientists from academia, government and industry, developing solutions for Fusarium infection in wheat. Infection by Fusarium is a global problem in cereal crops which can result in severe yield loss as well as an accumulation of toxin in the grain. The team is using a combination of breeding and genomics methods to understand the disease and develop new varieties of wheat for producers in both countries. In 2008 progress in identifying wheat types with enhanced resistance to Fusarium resulted in the presentation of an award to the research team from the City of Freising, Germany.

2.2 As part of a team of 23 researchers from 6 countries AAFC scientists contributed to constructing a physical map of wheat chromosome 3B which is the first step toward sequencing the first chromosome of wheat. Each wheat chromosome is about the size of the entire rice genome so sequencing of wheat is a massive project. AAFC expertise in genetic mapping was used to assist colleagues at INRA (France) with ordering more than 1,400 genetic markers on chromosome 3B, which was critical for ordering the bacterial artificial chromosome (BAC) clones and contigs in preparation for future sequencing of the chromosome. The work was reported in the prestigious journal Science.

2.3 In 1975 a major virulence factor in Phytophthora root rot of soybean was described. Despite many efforts over the last 35 years it was not possible to conclusively identify this factor until AAFC scientists reported the genetic sequence and description of the Avr1a factor in 2009. The identification of Avr1a adds to a growing list of P. sojae Avr factors that have recently been identified. These successes in finding Avr factors have been driven by technological changes such as genome sequencing and advances in knowledge. The isolation of P. sojae Avr1a is notable, given its long history in molecular plant pathology, but more importantly the identification of the Avr genes in Phytophthora sojae will aid pathogen diagnostics and cultivar development for one of the world's largest crops. A more rational approach to soybean breeding, diagnostics, and cultivar deployment will arise from such solid genetic information. It will also lead to a better mechanistic understanding of disease and how it may be managed.

2.4 A serious fungal pathogen of cereal crops such as wheat, barley, and corn, Fusarium graminearum produces a number of toxic metabolites or mycotoxins that accumulate in infected grain. Using a proteomics approach, AAFC researchers were able to identify hundreds of Fusarium proteins that were present when the fungus is induced to synthesize these mycotoxins. The relative quantities of seventy-two proteins increased significantly with the induction of mycotoxin production and provide leads in the search for mechanisms and markers of plant disease and novel antifungal targets.

2.5 Sclerotinia sclerotiorum is a necrotrophic plant pathogen that infects important agricultural crops including canola (Brassica napus), soybean (Glycine max) and sunflower (Helianthus annuus) (Boland and Hall, 1994). It secretes a battery of enzymes that break down plant tissues including polygalacturonases (PG), pectin lyases, pectin methyl and acetyl esterases that degrade plant pectin. Most plants genomes encode a limited set of polygalacturonase inhibitor proteins PGIP) that may inactivate the PG secreted by pathogens. AAFC scientists characterized a diverse set of 16 PGIP Brassica napus genes. Several BnPgip genes responded to infection by S. sclerotiorum or were responsive to other stresses and signalling molecules. The large number of PGIP genes and the different manners in which they are regulated likely ensures that B. napus can respond to attack from a broad spectrum of pathogens and pests. These are currently being examined for their ability to provide resistance to diseases caused by fungal pathogens.

2.6 Baculoviruses are insect specific and have proved to be effective insect control agents that are non-harmful to both the environment and humans. As baculoviruses have been identified for many insects of economic importance they represent a significant resource for the future development of organic insecticides. The baculovirus Autographa californica nucleopolyhedrovirus has the broadest host range of any known baculovirus. These studies have been investigating key genes that baculovirus genomics have identified to be present in all baculovirus species completely sequenced to date. Conservation of these genes suggest they play critical roles in virus replication By generating viruses that have these genes (ac142 and ac143) deleted from the genome we have shown they are critical for virus replication. One of them ac142 appears to be essential for recruiting membranes to virus particles a unique property. These studies will help to understand the molecular basis of baculovirus disease and lead to improved use of these natural agents as insect control agents.

2.7 The NRC Biorenewable Oil for Food and Fuel team is characterizing 29 genes that may play an important role in canola crop improvement. Elite candidate genes will be incorporated into the pre-commercialization. Five prototypes were tested in the field during the first year in collaboration with AAFC. Compared to the controls, two prototypes confirmed improved oil content and one prototype confirmed early flowering and increased seed size. The summary outputs of the program include the publication of 11 papers in refereed journals, 18 other publications / presentations / book chapters and one patent application. PIs from this program have established formal international collaborations with scientists from Germany, the Netherlands, China and India in areas directly related to the objectives of the program.

3. Sustainable management of aquatic resources through the use of genomics tools to: manage fishery openings; generate increased understanding of population genetics and structure; further understanding of behavioural, physiological and immunological responses to the environment; and through the management of aquatic animal diseases.

3.1 Manage fishery openings - DFO continues to develop information geared at understanding the changing behaviour of fish stocks due to climate change and pollution. Genomics tools including gene expression profiling are being used by DFO to determine physiological changes along the migration route to natal streams that is associated with early entry, a behavioural shift in late run Fraser River sockeye salmon. This research directly feeds into the management of fisheries openings through the 1) use of functional genomics technology in fisheries management, 2) use of wild caught organisms in large-scale ecological genomics research.

3.2 Increased understanding of population genetics and structure - Adding to previous work, several new projects were undertaken in order to understand the population structure of various species of socio-economic importance, including wild salmon, capelin, redfish, arctic char and beluga whales.

3.3 Further understanding of behavioural, physiological and immunological responses to the environment - Predictive biomarkers are being developed for monitoring relevant genes to enable pre-season prediction of migration behaviour and fish survival of pacific salmon for fishery managers in order to monitor the impacts of climate change and pollution.

3.4 Management of aquatic animal diseases - DFO continues to study aquatic animal diseases of import, such as the immune function of salmon and disease resistance against infectious salmon anemia virus (ISAV), a major pathogen of Atlantic salmon The viral mechanisms leading either to fish death or survival and resistance is not well understood at the immune or molecular levels. Another project includes using a functional genomics approach to characterising salmonid responses to the salmon louse, a distinct cause for concern for Pacific salmon growers

3.5 Monitor and mitigation of environmental contaminants including invasive species - New projects were undertaken to monitor and mitigate the effects of environmental contaminants. One project seeks to characterize microbial populations from produced water and its influence on the microbial community in the marine environment around the Hibernia Production Platform. A further project looks at the application of genetic markers to resolve species identification and population structure of invasive tunicate species.

4. Positioning the Canadian regulatory system for health to enable innovation while minimizing the risks to Canadians through a focused genomics R&D program aimed at strengthening capacity in priority areas such as genetic information, biotechnology products, human genomics and microbial genomics, on human, animal and environmental health.

4.1 Molecular Genomics Applied to Radiation Risk Assessment: Specialized custom-exposure systems have been constructed and characterized for radiofrequency (RF) fields and alpha-radiation for use in this project. Differential gene expression has been assessed in three human derived cell-lines after exposure to alpha-radiation. A list of alpha-radiation responsive genes has been generated and validated by RT-PCR.

4.2 Environmental Health Applications of toxico-genomics and proteomics. Identification of exposure and effect biomarkers for mutagenic carcinogens in complex environmental matrices: Gene expression responsive to low concentrations of diesel exhaust (SRM 1650b) using high density microarrays is completed and bioinformatic analysis is underway. In addition, genomics funding is being used to train additional HC staff. Thirteen proteins were identified as being potential candidate biomarkers of exposure for mutagenic carcinogens in complex environmental matrices. Confirmation and validation of the method are currently under investigation.

4.3 Development and validation of toxicogenomic tools, and integrated systems biology approaches in regulatory toxicology: Confirmation and validation of gene expression responsive and measured following low (environmentally-relevant) doses and further development of the NOTEL (no observable transcript effect level) below the doses inducing histological or biochemical changes. The following research methodologies were developed for identification and investigation of biomarkers. Technical validation of microRNA arrays: cross-platform correlation, sample storage, quality control/assurance development and statistical analysis. Biological validation of an in vitro mutation screening cell line (FE1) using DNA microarrays - comparison of response in vitro versus in vivo. Establishing the biological activity and the similarities/differences to the cells in vivo to improve interpretation of data acquired using in vitro systems. Use of ChIP-chip to identify regions of DNA that bind the thyroid receptor in the brains of developing mice. New reporter assays are being developed to identify chemicals which operate through disruption of TH pathways. Explorations of the cardio-pulmonary health effects of inhaled nanoparticles in utero (ongoing) and in the adult and induction of acute phase response.

4.4 Investigations on Colon Epithelial Cell Genetic Responses to Dietary Fibre were been established. The changes manifested in the intestinal bacteria will be used to determine what influence these changes may have on colonocyte responses. This work also represents methodological development for later work in this rat system.

4.5 Cell lines expressing a number of viral immunomodulatory proteins have been constructed. These include the influenza virus NS1 protein and the HCV NS3/NS4a proteins. MiRNA gene expression has been determined in these cell lines and a number of deregulated MiRNAs have been identified. MiRNAs expressed by microglia in the brains of prion infected mice have also been identified. Potential targets of one of these MiRNAs have been identified using a combination of functional genomic analyses.

4.6 Prototype gene and microarray assays to genotype Campilobacter jejuni samples per day were developed and tested, and are currently being deployed to perform molecular epidemiological analysis of various datasets, and used to investigate genome variability among virulent C. jejuni isolates that are highly prevalent among human clinical cases.

4.7 Work is undertaken to generate, synthesize, and translate new knowledge in pathogen and human genomics and related sciences (proteomics, transcriptomics, bioinformatics, etc.) to: strengthen infectious disease surveillance, prevention and control through applications such as diagnostics, molecular risk assessment, vaccines, intervention strategies, mitigation of antimicrobial resistance; and, develop applications to diagnose and prevent diseases and promote health through predictive genetic screening and/or modulation of gene-environment interactions.

5. Increased knowledge for forest generation and protection methods, and for addressing environmental impact considerations, through a focused genomics R&D effort on species and traits that are of economic importance to Canada.

5.1 The production of effective biological control methods based on genomics requires the understanding of the interactions between host and pathogen. Novel genomic resources were created by CFS researchers for two indigenous pests and one alien invasive pest. Eight cDNA libraries were created: one for the white tussock moth, two for the hemlock looper and five for the Emerald Ash Borer (EAB). Other investigations of pest species found the existence of microsporidia, a group of unicellular insect pathogens, in Mountain Pine Beetles (MPB) from 4 of the 10 collection sites and in one population of EAB. Several isolates of fungal pathogens were found in field collections of MPB from old infestations sites. Furthermore, primers were developed for various viruses of coleopteran species.

5.2 Early evidence has shown that the co-evolution of insects and their viruses also saw a co-dependency of the interacting proteins to initiate and establish infection in the host. Research on the occlusion derived virus of the balsam fir sawfly led to the identification of 18 proteins, three of which are novel.

5.3 Building on the genome scan performed by NRCan scientists in 2007-08, QTL analysis was completed and it was determined that bud flush, bud set and growth characters are mainly controlled by 7, 14 and 9 genomic regions respectively. Refinement of the QTL results is underway by association analysis. A high density genetic map of white spruce is in development to position 1800 of the 28000 genes (identified by the Arborea effort). This is the starting point of a physical map for spruce.

5.4 In white spruce, 214 candidate genes were rated as high priority and are being used to search for variants in association studies. Exploratory association studies identified 6 to 20 polymorphic SNPs to be significantly associated with one of the 25 wood traits investigated. White spruce primers were tested on black spruce DNA, identifying over 1800 SNPs. Primers were designed for candidate genes relating to wood formation.

5.5 2008-09 saw novel discoveries in the white pine-blister rust interaction, the identification of proteins and genes that function in disease resistance. In collaboration with the USDA-FS and BC Ministry of Forest and Range, several white pine candidate genes were investigated for single nucleotide polymorphisms (SNPs) and SNP genetic association with resistance phenotypes in multiple white pine families with quantitative resistance phenotypes. Research on Douglas Fir (DF) identified defence related proteins in DF roots infected with laminated root rot. Further testing is underway on 45 genes with potential pathogenicity function.

6. Development of genome-science applications to support regulatory and enforcement activities in key areas such as environmental risk assessment and management; enforcement and compliance; pollution detection, monitoring and prevention; conservation biology and wildlife genetics; technology forecasting and assessment; and the responsible and sustainable development and use of bio-based products and industrial processes.

6.1 In 2008-09 EC made significant advances in the application of the genomic tools and data that have been generated over the life span of the GRDI. Using GRDI funding, EC developed an in-situ technique to conduct pathogenicity and toxicity testing of microbial substances in soil which has helped to validate a new national guidance document under the Canadian Environmental Protection Act. EC has also developed and applied genomics methods to investigate the toxic effects of environmental contaminants on aquatic microbial communities. This research has lead to the application of tools and approaches for assessing priority substances and emerging contaminants such as personal care products and pharmaceuticals. EC's wildlife research has provided the scientific (genomic) data in which conservation and wildlife management decisions (i.e for bird species Yellow-breasted chats, Ontario's goose populations, Loggerhead Shrikes etc.) have been based (both at the federal and provincial level).

6.2 Numerous environmental genomics-based approaches were used in 2008-09 by EC:

  • Application of genomics to microbial source tracking: Identification of genetic markers specific for animal fecal pollution in aquatic environments.
  • Application of genomics in environmental risk assessment.
  • Validation of genomics tools for the prediction of environmental effects: response of fish to contaminated sediments.
  • Development and validation of a lobster eco-toxicogenomic array - Correlation of gene expression profiles with traditional toxicological end-points for contaminant exposure, histological effects, and behavioural changes.
  • Environmental safety of biotechnology to aquatic ecosystems - Impacts of transgenic crops and commercial bacterial consortia to aquatic invertebrates.
  • Application of genomics to monitor the health and activities of microbial communities in contaminated soils and stressed riverine environments.
  • Gene expression technologies - Application of genomics to wildlife toxicology.
  • Application of genomics methods and end-point measurements for aquatic toxicological testing and environmental effects monitoring.
  • Development and application of novel genomics-based techniques for the detection of environmental microorganisms and the assessment of chronic toxicity in wastewater.
  • Development and standardization of test methods using environmental genomics techniques.
  • Breeding behavior and population history of the red-listed Yellow-breasted chat in British Columbia.
  • Establishing molecular assessment techniques for emerging infectious diseases in native amphibians; laboratory and sampling technique comparisons.
  • Comparative Genetic Diversity of Captive and Wild of Loggerhead Shrikes.
  • Conservation Genetics of Leach's Storm-petrels.
  • Genetic characterization of strains of Pasteurella multocida isolated from large-scale avian cholera outbreaks across Canada.
  • Ontario Canada goose population harvest discrimination.
  • Characterization and sequencing of avian influenza viruses from birds in eastern Newfoundland.
  • Hybridization between Eastern wolves (Canis lycaon) and other canids: An example of contemporary evolution in human-modified landscapes.

Comments on Variances:

The discrepancy was due to the fact that funds were not cash managed in advance of the approval of the TB Submission (in September), and funds did not get transferred from Health Canada to PHAC until December 2008. Hence, all PHAC projects were only initiated in January 2009 (3 months of activity and not 12). However, these funds will not be lost as they are being recovered through the annual carry-over allotment for PHAC of 5%, bringing the Year 1 expenditures to 93.2%. Expenditures in Year 2 will be for the Year 1 and Year 2 totals.

Results to be achieved by non-federal partners (if applicable): N/A

Contact information:

Gary Fudge, P. Eng.
Director, Life Sciences Horizontal Initiatives
National Research Council
613-949-0542




Table 9: Green Procurement

Meeting Policy Requirements

Has the department incorporated environmental performance considerations in its procurement decision-making processes?

In progress

Summary of initiatives to incorporate environmental performance considerations in procurement decision-making processes:

Green Procurement and environmental performance considerations are evolving and being implemented at NRC. Green procurement has been discussed and reviewed with procurement officers. Green procurement reporting has been developed and implemented in NRC's SAP business system. Procurement officers have access to and use PWGSC-established Green Standing Offers for various commodities.

In addition, in 2008/09 NRC made major capital environmental investments in its facilites, has conducted environmental reviews of facilities and lands, completed storage tank replacements, implemented environmental action in its reprographic operations, addressed cleaning contract products, and fluorescent tube recycling.

Results achieved:

  1. NRC has made major capitalization investment in our facilities across Canada, including $2.6 million on building envelope improvement, and $0.6 million on upgrading control systems and $0.7 million on upgrading building chiller systems. These have improved energy efficiency in our facilities, thereby reducing green house gas and ozone depleting substances and emissions;
  2. NRC is conducting environmental operational reviews and site assessments at all major facilities and land uses to ensure compliance with envirnmental regulations and to identify potential environmental liabilities;
  3. NRC completed the final phase of replacing underground storage tank systems. NRC has completed a compliance audit of all federal regulated tank systems to ensure compliance with the new regulations;
  4. NRC's reprographic operations has initiated use of vegetable based inks, used paper with post and pre consumer waste where possible, initiated a recycling program for metal plates, initiated a chemical recycling unit on the plate processor, and has installed a silver recovery and pH neutralizer system on the plate processor;
  5. NRC has initiated cleaning contracts that require environmentally friendly products;
  6. NRC has streamlined the Fluorescent Tube Recycling Program in the NCR;
  7. Converted printed engineering drawings for the government tendering process to electronic format;
  8. Vehicle replacements and purchases were made earlier in the fiscal year to ensure vehicle availablity that meets the intended use, has acceptable service costs and fuel efficiency.

Contributions to facilitate government-wide implementation of green procurement:

NRC's procurement management has participated in meetings at PWGSC's Client Advisory Board and with the OGGO to stay abreast of developments in green procurement and to develop improved green procurement plans and reporting. At a recent national materiel management (MM) meeting of procurement and MM staff, a green procurement session was facilitated with the aim of developing a comprehensive program including training, reporting and enhanced environmental considerations in the 4 phases of life cycle management of materials.

Green Procurement Targets

Has the department established green procurement targets?

In progress

For 2008/09, NRC reported that this was "In progress". Specific targets were not established but various initiatives had been planned, some of which were identified in the Results Achieved section above.

Are these green procurement targets the same as those identified in your Sustainable Development Strategy?

Not applicable

Summary of green procurement targets:

Not applicable, as NRC reported these as being "In progress"

Results achieved:

Not applicable



Table 10: Response to Parliamentary Committees and External Audits


Response to Parliamentary Committees
N/A
Response to the Auditor General (including to the Commissioner of the Environment and Sustainable Development)
The OAG made recommendations emanating from their performance audit in 2004 of NRC Management of Leading Edge Research and its follow-up in 2007 pertaining to governance, human resource management, business planning, research project management and performance data collection and reporting. All of the recommendations have been fully implemented except for two areas; however, much progress has been made leading us to assess their implementation as "substantially completed" in accordance with OAG assessment guidelines. Those areas requiring further implementation pertain to the collection and reporting of performance data and research project documentation which are anticipated to be fully implemented by the end of 2009-10. Web links: 2004 report; 2007 report.

The OAG made only one recommendation emanating from its performance report in May 2009 of Intellectual Property; specifically that we identify more accurately the intellectual property expected to result from Crown procurement contracts and ensure it is accurately reported. A detailed management action plan has been put in place that is expected to fully address this recommendation by November 2009.
External Audits (Note: These refer to other external audits conducted by the Public Service Commission of Canada or the Office of the Commissioner of Official Languages)
N/A



Table 11: Internal Audits and Evaluations

Table 11a: Internal Audits (current reporting period)


Name of Internal Audit Audit Type Status Completion Date
Audit of Construction Contracts Procurement and Contracting; Management control framework and compliance audit Completed January 2009
Audit of Contracts over $25,000 – 2007-2008 Procurement and Contracting; Management control framework and compliance audit Completed January 2009
Audit of Hospitality – 2007-2008 Procurement and Contracting; Management control framework and compliance audit Completed January 2009
Audit of Travel – 2007-2008 Procurement and Contracting; Management control framework and compliance audit Completed January 2009
Review of Values and Ethics Values and Ethics; Audit Survey Completed June 2009
Audit of Facilities Management and Equipment Real Property Management; Management control framework and compliance audit In progress October 2009
Audit of Acquisition Cards – 2008-2009 Financial Management; Management control framework and compliance audit In progress October 2009
Audit of Occupational Health and Safety Real Property Management; Management control framework and compliance audit In progress October 2009
Audit of Integrated Risk Management Risk Management; Management controls framework audit In progress October 2009

Approved Audit Reports are posted on the National Research Council's web site

Table 11b: Evaluations (current reporting period)


Name of Evaluation Program Activity Program Type Status Completion Date
Evaluation of the National Research Council's Fuel Cell and Hydrogen Program   Formative Completed 2008-09
Report of the Peer Review Committee of TRIUMF   Summative Completed 2008-09
Summative Evaluation of the Youth Employment Strategy   Summative In progress 2009-10
Portfolio Evaluation of the NRC Technology Cluster Initiatives   Summative In progress 2009-10
Portfolio Evaluation of the Institute for National Measurement Standards   Summative In progress 2009-10